abstract：:Evidence indicates that oxidative stress-induced damage to DNA, protein, and other cellular components contributes to the progression of Alzheimer's disease (AD). Several studies indicate that postmitotic neurons have a reduced capacity for some types of DNA repair, which is further compromised by aging. Thus in AD, t...

journal_title：Neurobiology of aging

authors： Shackelford DA

更新日期：2006-04-01 00:00:00

abstract：:An extensive literature reports changes in quantitative electroencephalogram (QEEG) with aging and a relationship between magnitude of changes and degree of clinical deterioration in progressive dementia. Longitudinal studies have demonstrated QEEG differences between mild cognitively impaired (MCI) elderly who go on ...

journal_title：Neurobiology of aging

authors： Prichep LS,John ER,Ferris SH,Rausch L,Fang Z,Cancro R,Torossian C,Reisberg B

更新日期：2006-03-01 00:00:00

abstract：:Multiple degenerative hallmarks characterize Alzheimer's disease: insoluble protein deposition, neuronal loss and cortical atrophy. Atrophy begins in the medial temporal lobe and becomes global by end stage. In a small proportion of cases, these tissue changes are caused by mutations in three known genes. These cases ...

journal_title：Neurobiology of aging

authors： Gregory GC,Macdonald V,Schofield PR,Kril JJ,Halliday GM

更新日期：2006-03-01 00:00:00

abstract：:Raising insulin acutely in the periphery and in brain improves verbal memory. Intranasal insulin administration, which raises insulin acutely in the CNS without raising plasma insulin levels, provides an opportunity to determine whether these effects are mediated by central insulin or peripheral processes. Based on pr...

journal_title：Neurobiology of aging

authors： Reger MA,Watson GS,Frey WH 2nd,Baker LD,Cholerton B,Keeling ML,Belongia DA,Fishel MA,Plymate SR,Schellenberg GD,Cherrier MM,Craft S

更新日期：2006-03-01 00:00:00

abstract：:We determined whether oxidative stress is an early event in the pathogenesis of sporadic Alzheimer disease (AD), and correlated oxidative stress with neuropsychological functions and neurofibrillary pathology in AD and mild cognitive impairment (MCI). Oxidative stress was measured as the percentage of astrocytes expre...

journal_title：Neurobiology of aging

authors： Schipper HM,Bennett DA,Liberman A,Bienias JL,Schneider JA,Kelly J,Arvanitakis Z

更新日期：2006-02-01 00:00:00

abstract：:Vergence eye movements were recorded with the scleral search-coil system in 32 healthy subjects (ages 19-73 years) to characterize the age-related effects on the dynamic parameters of vergence responses to step (transient components) and ramp or sinusoidal targets (sustained components) under natural viewing condition...

journal_title：Neurobiology of aging

authors： Rambold H,Neumann G,Sander T,Helmchen C

更新日期：2006-01-01 00:00:00

abstract：:There is a large body of evidence highlighting the importance of oxidative stress in the pathogenesis of Alzheimer's disease (AD). We have previously standardised a method that can be applied to study oxidative changes in individual brain proteins by using two-dimensional oxyblots (Korolainen MA, Goldsteins G, Alafuzo...

journal_title：Neurobiology of aging

authors： Korolainen MA,Goldsteins G,Nyman TA,Alafuzoff I,Koistinaho J,Pirttilä T

更新日期：2006-01-01 00:00:00

abstract：:We present a fresh approach to evaluating association with candidate genes and cognitive change by testing association for parameters describing individual growth curves from twins. Moderate genetic influences on memory in aging adults has been shown in quantitative genetic studies. A recently reported, association of...

journal_title：Neurobiology of aging

authors： Reynolds CA,Jansson M,Gatz M,Pedersen NL

更新日期：2006-01-01 00:00:00

abstract：:Results from basic and clinical studies demonstrate that stress and depression decrease neurotrophic factor expression and neurogenesis in brain, and that antidepressant treatment blocks or reverses these effects, leading to a neurotrophic hypothesis of depression. Neurotrophic factor expression and neurogenesis are a...

journal_title：Neurobiology of aging

authors： Duman RS

更新日期：2005-12-01 00:00:00

abstract：:We used high-resolution MRI to investigate gray and white matter aging in the major lobes of the cerebrum (frontal, parietal, temporal, occipital) and the major sectors of the temporal lobe (temporal pole, superior temporal gyrus, infero-temporal region, parahippocampal gyrus, amygdala, hippocampus). Subjects included...

journal_title：Neurobiology of aging

authors： Allen JS,Bruss J,Brown CK,Damasio H

更新日期：2005-10-01 00:00:00

abstract：:Plaques found in the brains of patients suffering from Alzheimer's disease (AD) mainly consist of beta-amyloid (Abeta), which is produced by sequential cleaving of amyloid precursor protein (APP) by two proteolytic enzymes, beta- and gamma-secretases. Any change in the fine balance between these enzymes and their subs...

journal_title：Neurobiology of aging

authors： Zohar O,Pick CG,Cavallaro S,Chapman J,Katzav A,Milman A,Alkon DL

更新日期：2005-08-01 00:00:00

abstract：:Recent studies suggested that matrix metalloproteinases (MMPs) might play an important role in the pathophysiology of Alzheimer's disease (AD). MMP-9 and MMP-3 are reported to degrade amyloid beta and have several functional polymorphisms associated with other common diseases. Four common polymorphisms in each of MMP-...

journal_title：Neurobiology of aging

authors： Shibata N,Ohnuma T,Higashi S,Usui C,Ohkubo T,Kitajima A,Ueki A,Nagao M,Arai H

更新日期：2005-07-01 00:00:00

abstract：:Aged rats perform poorly on spatial learning tasks, a cognitive impairment which has been linked to the failure of hippocampal networks to fully encode changes in the external environment [Barnes CA, Suster MS, Shen J, McNaughton BL. Multistability of cognitive maps in the hippocampus of old rats. Nature 1997;388(6639...

journal_title：Neurobiology of aging

authors： Wilson IA,Ikonen S,Gurevicius K,McMahan RW,Gallagher M,Eichenbaum H,Tanila H

更新日期：2005-07-01 00:00:00

abstract：:Altered glutamate transport and aberrant EAAT1 expression were shown in Alzheimer's disease (AD) brains. It is presently unknown whether these modifications are a consequence of neurodegeneration or play a pathogenetic role. However, recent findings of decreased glutamate uptake, EAAT1 protein and mRNA in AD platelets...

journal_title：Neurobiology of aging

authors： Zoia CP,Tagliabue E,Isella V,Begni B,Fumagalli L,Brighina L,Appollonio I,Racchi M,Ferrarese C

更新日期：2005-06-01 00:00:00

abstract：:Energy deficiency and dysfunction of the Na,K-ATPase are common consequences of many pathological insults. Glutamate through cyclic GMP and cyclic GMP-dependent protein kinase (PKG) has been shown to stimulate alpha(2/3)-Na,K-ATPase activity in the central nervous system. Thus, a slight impairment of this pathway may ...

journal_title：Neurobiology of aging

authors： Scavone C,Munhoz CD,Kawamoto EM,Glezer I,de Sá Lima L,Marcourakis T,Markus RP

更新日期：2005-06-01 00:00:00

abstract：:To obtain information on the mechanisms responsible of the generation of ragged red fibers (RRF) during aging, we analyzed the mitochondrial genotype of single skeletal muscle fibers of healthy individuals having an age comprised between 45 and 92 years. The sequencing of the D-loop region showed many sequence changes...

journal_title：Neurobiology of aging

authors： Cormio A,Milella F,Vecchiet J,Felzani G,Gadaleta MN,Cantatore P

更新日期：2005-05-01 00:00:00

abstract：:The current study describes both Abeta and tau abnormalities that accumulate in the brains of aged (16-21 years), but not young (<4 years) clinically characterized cats. Diffuse plaques that were morphologically different from what is typically observed in the human brain could be detected with 4G8 (Abeta17-24) or an ...

journal_title：Neurobiology of aging

authors： Head E,Moffat K,Das P,Sarsoza F,Poon WW,Landsberg G,Cotman CW,Murphy MP

更新日期：2005-05-01 00:00:00

abstract：:The effects of beta-amyloid peptide25-35 on resting membrane potential, spontaneous and evoked action potential and synaptic activity have been studied in basolateral amygdaloid complex on slices obtained from adult rats. Intracellular recordings reveal that perfusion with beta-amyloid peptide25-35 at concentrations o...

journal_title：Neurobiology of aging

authors： Ashenafi S,Fuente A,Criado JM,Riolobos AS,Heredia M,Yajeya J

更新日期：2005-04-01 00:00:00

abstract：:Decreases in the activity or density of dopamine D2 receptor (D2R) have been associated with age-related changes and neurodegenerative diseases such as Parkinson's disease. There are two isoforms of the D2R, termed the D2 long receptor (D2LR) and D2 short receptor (D2SR). To study the function of these two isoforms an...

journal_title：Neurobiology of aging

authors： Fetsko LA,Xu R,Wang Y

更新日期：2005-04-01 00:00:00

abstract：:To investigate developmental and vascular risk factors for Alzheimer's disease (AD), we examined 90 incident cases of probable AD in a cohort of 1859 individuals followed prospectively for six years. The presence of the APOE-epsilon4 allele was the strongest risk factor, and with increasing survival age, the effect of...

journal_title：Neurobiology of aging

authors： Borenstein AR,Wu Y,Mortimer JA,Schellenberg GD,McCormick WC,Bowen JD,McCurry S,Larson EB

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:We used positron emission tomography to evaluate cerebral glucose metabolic change in postmenopausal women in a naturalistic observational study. METHOD:Women estrogen users (n = 11) and non-users (n = 9) were studied at baseline and 2 years later. Analyses focused on glucose metabolism in regions previously...

journal_title：Neurobiology of aging

authors： Rasgon NL,Silverman D,Siddarth P,Miller K,Ercoli LM,Elman S,Lavretsky H,Huang SC,Phelps ME,Small GW

更新日期：2005-02-01 00:00:00

abstract：:The low density lipoprotein receptor (LDLR) is an attractive candidate gene for genetic association with Alzheimer's disease (AD) because: (i) the LDLR is an apolipoprotein E (apoE) receptor, alleles of which have been associated with AD, (ii) LDLR resides at chromosome 19p13.3 within a region linked to AD, and (iii) ...

journal_title：Neurobiology of aging

authors： Gopalraj RK,Zhu H,Kelly JF,Mendiondo M,Pulliam JF,Bennett DA,Estus S

更新日期：2005-01-01 00:00:00

abstract：:Age-dependent cognitive impairments have been correlated with functional and structural modifications in the hippocampal formation. In particular, the brain endogenous steroid pregnenolone-sulfate (Preg-S) is a cognitive enhancer whose hippocampal levels have been linked physiologically to cognitive performance in sen...

journal_title：Neurobiology of aging

authors： Mayo W,Lemaire V,Malaterre J,Rodriguez JJ,Cayre M,Stewart MG,Kharouby M,Rougon G,Le Moal M,Piazza PV,Abrous DN

更新日期：2005-01-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of synaptic plasticity in the adult brain and acute BDNF infusion has been shown to trigger long-term potentiation (BDNF-LTP) in adult rats. Here we compared the effects of acute BDNF infusion in young adult and aged anesthetized rats. In young ...

journal_title：Neurobiology of aging

authors： Gooney M,Messaoudi E,Maher FO,Bramham CR,Lynch MA

更新日期：2004-11-01 00:00:00

abstract：:Amyloid beta (A beta) immunization of amyloid precursor protein (APP)-transgenic (tg) mice with human A beta induces humoral immunity, however, the immune response to endogenous rodent A beta is unknown. Fourteen-month J20 APP-tg mice and non-tg littermates were immunized subcutaneously followed by chronic intranasal ...

journal_title：Neurobiology of aging

authors： Seabrook TJ,Bloom JK,Iglesias M,Spooner ET,Walsh DM,Lemere CA

更新日期：2004-10-01 00:00:00

abstract：:The effect of aging on acquisition of a learned suppression of photopositive tendencies was studied in 1-7-week-old flies of both sexes. Flies had to choose in a T-maze between an alley leading to a lighted vial associated with an aversive stimulus, a quinine hydrochloride solution, and another alley leading to a dark...

journal_title：Neurobiology of aging

authors： Le Bourg E

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD). METHODS:25 patients with mild FTD and 9 patients with mild SD as well as 15 healthy age-matched control subjects underwent 18F-FDG- positron emission tomography. Patient scans were compared w...

journal_title：Neurobiology of aging

authors： Diehl J,Grimmer T,Drzezga A,Riemenschneider M,Förstl H,Kurz A

更新日期：2004-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline leading to dementia and involves the deposition of amyloid-beta (Abeta) peptides into senile plaques. Other neuropathological features that accompany progression of the disease include a decrease in synaptic density, neurofibrillary tangles, ...

journal_title：Neurobiology of aging

authors： Dudal S,Krzywkowski P,Paquette J,Morissette C,Lacombe D,Tremblay P,Gervais F

更新日期：2004-08-01 00:00:00

abstract：:Previously, we demonstrated that plasticity of frontal cortex is altered in aging rats: 3 months after surgery, excitotoxic lesions of the nucleus basalis magnocellularis (NBM) produce larger declines in dendritic morphology in frontal cortex of aged rats relative to young adults. To determine whether the differential...

journal_title：Neurobiology of aging

authors： Works SJ,Wilson RE,Wellman CL

更新日期：2004-08-01 00:00:00

abstract：:Increasing evidence suggests that cholesterol plays a central role in the pathophysiology of Alzheimer's disease (AD). Caveolin is a cholesterol-binding membrane protein involved in cellular cholesterol transport. We investigated the changes in the protein amount of hippocampal caveolin of autopsy-confirmed AD and age...

journal_title：Neurobiology of aging

authors： Gaudreault SB,Dea D,Poirier J

更新日期：2004-07-01 00:00:00

abstract：:Despite very numerous studies on Alzheimer's disease (AD), especially on amyloid plaques and neurofibrillary tangles, little information has been obtained thus on the causes of the disease. Evidence is described here that implicates firstly herpes simplex virus type 1 (HSV1) as a strong risk factor when it is present ...

journal_title：Neurobiology of aging

authors： Itzhaki RF,Wozniak MA,Appelt DM,Balin BJ

更新日期：2004-05-01 00:00:00

abstract：:Compared to young rats, old age increases susceptibility and caloric restriction decreases susceptibility for the loss of retinal ganglion cells and displaced amacrine cells following retinal ischemia/reperfusion. In retinas of old animals before ischemia, reactive gliosis, including activation of Muller cells, microg...

journal_title：Neurobiology of aging

authors： Kim KY,Ju WK,Neufeld AH

更新日期：2004-04-01 00:00:00

abstract：:In the axon terminals of the locus coeruleus (LC) neurons, a high level of axonal branching was occurred in the middle-aged brain, and the increased branching was maintained in the aged brain. In the present study, we hypothesized that neurotrophic support is necessary for the morphological age-related changes seen in...

journal_title：Neurobiology of aging

authors： Matsunaga W,Shirokawa T,Isobe K

更新日期：2004-03-01 00:00:00

abstract：:Aged rats show decrements in performance on cognitive tasks that require the use of spatial learning and memory. We used the 8-arm radial water maze (RAWM) to measure spatial learning as a function of age in young (6 months) and old (21 months) male F344 rats. Rats were placed in the RAWM in different start arms with ...

journal_title：Neurobiology of aging

authors： Shukitt-Hale B,McEwen JJ,Szprengiel A,Joseph JA

更新日期：2004-02-01 00:00:00

abstract：:It is widely known that the tau protein that forms the aggregates found in tauopathies like Alzheimer's disease (AD) is hyperphosphorylated. Many of the sites that are hyperphosphorylated in AD can also be found phosphorylated in non-pathological control brains, although to a lesser extend. Among the different kinases...

journal_title：Neurobiology of aging

authors： Hernández F,Lucas JJ,Cuadros R,Avila J

更新日期：2003-12-01 00:00:00

abstract：:In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids inc...

journal_title：Neurobiology of aging

authors： Rinaldi P,Polidori MC,Metastasio A,Mariani E,Mattioli P,Cherubini A,Catani M,Cecchetti R,Senin U,Mecocci P

更新日期：2003-11-01 00:00:00

abstract：:Age-related impairments in episodic memory have been related to a deficiency in semantic processing, based on the finding that elderly adults typically benefit less than young adults from deep, semantic as opposed to shallow, nonsemantic processing of study items. In the present study, we tested the hypothesis that el...

journal_title：Neurobiology of aging

authors： Daselaar SM,Veltman DJ,Rombouts SA,Raaijmakers JG,Jonker C

更新日期：2003-11-01 00:00:00

abstract：:Studies in vitro have suggested that acetylcholinesterase (AChE) may interact with beta-amyloid to promote deposition of amyloid plaques in the brain of patients with Alzheimer's disease. To test that hypothesis in vivo, we crossed Tg2576 mice, which express human amyloid precursor protein and develop plaques at 9 mon...

journal_title：Neurobiology of aging

authors： Rees T,Hammond PI,Soreq H,Younkin S,Brimijoin S

更新日期：2003-10-01 00:00:00

abstract：:Numerous types of age-related deficits in the nervous system have been well documented. While a distinction between general types of memories that are susceptible to compromise with advanced age has been fairly well agreed upon, it is often difficult to determine exactly which specific processes are detrimentally infl...

journal_title：Neurobiology of aging

authors： Churchill JD,Stanis JJ,Press C,Kushelev M,Greenough WT

更新日期：2003-10-01 00:00:00

abstract：:Alzheimer disease (AD) is characterised by a decrease of platelet Amyloid Precursor Protein forms ratio (APPr), which parallels symptoms' severity. Recent studies have suggested that cholesterol might play a role in the pathophysiology of AD by modulating Abeta production. Aim of this study was to evaluate the relatio...

journal_title：Neurobiology of aging

authors： Borroni B,Colciaghi F,Lenzi GL,Caimi L,Cattabeni F,Di Luca M,Padovani A

更新日期：2003-09-01 00:00:00